sln gel  (ATCC)

Journal: Pharmaceutics

Article Title: Lipid Systems for the Delivery of Amphotericin B in Antifungal Therapy

doi: 10.3390/pharmaceutics12010029

Figure Lengend Snippet: Lipid-based systems for delivery of amphotericin B currently under development.

Article Snippet: SLN gel , Skin , 111.1 ± 2.2 (0.13 ± 0.04) , 93.8 ± 1.8 , AmB:lipid (1:10 weight ratio), Pluronic F127 (0.25% w / v ). Solvent diffusion method in aqueous system. , Antifungal activity against Trichophyton rubrum (ATCC 28188, KWIK-STIK 0444P), ZOI (72 h) 2.81 ± 0.13 mm. Stability (ζ –23.98 ± 1.36 mV) at 2–8 °C and 25 ± 2 °C, for 3 months. AmB in aqueous phase: 90.2 ± 1.1% (compritol ATO 888), 96.5 ± 1.4% (Precirol ATO 5, selected for preparation of SLNs gel), and 72.1 ± 2.7% (stearic acid). Ex vivo permeation studies on abdomen skin of female albino Wistar rats: AmB efflux 22.34 μg/cm 2 . PII (SLN gel) 0.11 ± 0.19 Higher skin deposition, lower skin irritation, high antifungal activity, localized delivery with minimal side effects. , [ ] .

Techniques: Formulation, Conjugation Assay, Permeability, In Vitro, Activity Assay, Produced, MTT Assay, In Vivo, Concentration Assay, Spectroscopy, Shear, Liposomes, Modification, Dispersion, Injection, Incubation, Saline, Sonication, Infection, Solubility, Encapsulation, Homogenization, Titration, Ex Vivo, Viscosity, Inhibition, Diffusion-based Assay, Emulsion, Clinical Proteomics, Fluorescence, Imaging, Adjuvant, Expressing, RNA Expression, Solvent, Control, Histopathology, Polymer, Evaporation, Emulsification, Eye Drops

Journal: AAPS PharmSciTech

Article Title: Formulation of Topical Flurbiprofen Solid Lipid Nanoparticle Gel Formulation Using Hot Melt Extrusion Technique

doi: 10.1208/s12249-022-02410-w

Figure Lengend Snippet: Schematic representation of formulation of FLB SLN using HME technique

Article Snippet: Anti‐inflammatory Effect of FLB SLN In Vivo Three groups: no treatment, 0.5% FLB SLN gel, and 5% FLB gel marketed product of SD rats (Envigo, IN, USA) were divide for this experiment.

Techniques: Formulation

Journal: AAPS PharmSciTech

Article Title: Formulation of Topical Flurbiprofen Solid Lipid Nanoparticle Gel Formulation Using Hot Melt Extrusion Technique

doi: 10.1208/s12249-022-02410-w

Figure Lengend Snippet: A SEM image of FLB SLN showing spherical SLN particles with particle size below 250 nm. B DSC thermogram showing sharp endotherm of FLB at its melting point which was disappeared in FLB SLN formulation

Article Snippet: Anti‐inflammatory Effect of FLB SLN In Vivo Three groups: no treatment, 0.5% FLB SLN gel, and 5% FLB gel marketed product of SD rats (Envigo, IN, USA) were divide for this experiment.

Techniques: Formulation

Journal: AAPS PharmSciTech

Article Title: Formulation of Topical Flurbiprofen Solid Lipid Nanoparticle Gel Formulation Using Hot Melt Extrusion Technique

doi: 10.1208/s12249-022-02410-w

Figure Lengend Snippet: A Spreadability testing setup using texture analyzer equipment. B Spreadability curve showing significant decrease in peak adhesive force in case of 0.5% w/v FLB SLN formulation as compared to 5% w/w FLB marketed gel formulation

Article Snippet: Anti‐inflammatory Effect of FLB SLN In Vivo Three groups: no treatment, 0.5% FLB SLN gel, and 5% FLB gel marketed product of SD rats (Envigo, IN, USA) were divide for this experiment.

Techniques: Adhesive, Formulation

Journal: AAPS PharmSciTech

Article Title: Formulation of Topical Flurbiprofen Solid Lipid Nanoparticle Gel Formulation Using Hot Melt Extrusion Technique

doi: 10.1208/s12249-022-02410-w

Figure Lengend Snippet: Table Showing Peak Adhesive Force, Work Area, and Stiffness of 0.5% FLB SLN Gel and 5% Marketed FLB Gel

Article Snippet: Anti‐inflammatory Effect of FLB SLN In Vivo Three groups: no treatment, 0.5% FLB SLN gel, and 5% FLB gel marketed product of SD rats (Envigo, IN, USA) were divide for this experiment.

Techniques: Adhesive

Journal: AAPS PharmSciTech

Article Title: Formulation of Topical Flurbiprofen Solid Lipid Nanoparticle Gel Formulation Using Hot Melt Extrusion Technique

doi: 10.1208/s12249-022-02410-w

Figure Lengend Snippet: Rheological studies of 0.5% w/v FLB SLN gel and 5% w/w FLB marketed gel formulation showing decrease in viscosity upon increase in shear rate

Article Snippet: Anti‐inflammatory Effect of FLB SLN In Vivo Three groups: no treatment, 0.5% FLB SLN gel, and 5% FLB gel marketed product of SD rats (Envigo, IN, USA) were divide for this experiment.

Techniques: Formulation, Viscosity, Shear

Journal: AAPS PharmSciTech

Article Title: Formulation of Topical Flurbiprofen Solid Lipid Nanoparticle Gel Formulation Using Hot Melt Extrusion Technique

doi: 10.1208/s12249-022-02410-w

Figure Lengend Snippet: A In vitro permeation test (IVPT) showing significant increase in percent drug permeation in case of 0.5% w/v FLB SLN formulation as compared to 5% w/w FLB marketed gel formulation at the end of 24 h. B Skin deposition study showing significant increase in drug deposition in dermal layer in case of 0.5% w/v FLB SLN formulation as compared to 5% w/w FLB marketed gel formulation at the end of 24 h

Article Snippet: Anti‐inflammatory Effect of FLB SLN In Vivo Three groups: no treatment, 0.5% FLB SLN gel, and 5% FLB gel marketed product of SD rats (Envigo, IN, USA) were divide for this experiment.

Techniques: In Vitro, Formulation

Journal: AAPS PharmSciTech

Article Title: Formulation of Topical Flurbiprofen Solid Lipid Nanoparticle Gel Formulation Using Hot Melt Extrusion Technique

doi: 10.1208/s12249-022-02410-w

Figure Lengend Snippet: In vivo anti-inflammatory study showing equivalent edema inhibition effect after application of 0.5% w/v FLB SLN gel and 5% w/w marketed FLB gel

Article Snippet: Anti‐inflammatory Effect of FLB SLN In Vivo Three groups: no treatment, 0.5% FLB SLN gel, and 5% FLB gel marketed product of SD rats (Envigo, IN, USA) were divide for this experiment.

Techniques: In Vivo, Inhibition

Journal: AAPS PharmSciTech

Article Title: Formulation of Topical Flurbiprofen Solid Lipid Nanoparticle Gel Formulation Using Hot Melt Extrusion Technique

doi: 10.1208/s12249-022-02410-w

Figure Lengend Snippet: Schematic representation of formulation of FLB SLN using HME technique

Article Snippet: Three groups: no treatment, 0.5% FLB SLN gel, and 5% FLB gel marketed product of SD rats (Envigo, IN, USA) were divide for this experiment.

Techniques: Formulation

Journal: AAPS PharmSciTech

Article Title: Formulation of Topical Flurbiprofen Solid Lipid Nanoparticle Gel Formulation Using Hot Melt Extrusion Technique

doi: 10.1208/s12249-022-02410-w

Figure Lengend Snippet: A SEM image of FLB SLN showing spherical SLN particles with particle size below 250 nm. B DSC thermogram showing sharp endotherm of FLB at its melting point which was disappeared in FLB SLN formulation

Article Snippet: Three groups: no treatment, 0.5% FLB SLN gel, and 5% FLB gel marketed product of SD rats (Envigo, IN, USA) were divide for this experiment.

Techniques: Formulation

Journal: AAPS PharmSciTech

Article Title: Formulation of Topical Flurbiprofen Solid Lipid Nanoparticle Gel Formulation Using Hot Melt Extrusion Technique

doi: 10.1208/s12249-022-02410-w

Figure Lengend Snippet: A Spreadability testing setup using texture analyzer equipment. B Spreadability curve showing significant decrease in peak adhesive force in case of 0.5% w/v FLB SLN formulation as compared to 5% w/w FLB marketed gel formulation

Article Snippet: Three groups: no treatment, 0.5% FLB SLN gel, and 5% FLB gel marketed product of SD rats (Envigo, IN, USA) were divide for this experiment.

Techniques: Adhesive, Formulation

Journal: AAPS PharmSciTech

Article Title: Formulation of Topical Flurbiprofen Solid Lipid Nanoparticle Gel Formulation Using Hot Melt Extrusion Technique

doi: 10.1208/s12249-022-02410-w

Figure Lengend Snippet: Table Showing Peak Adhesive Force, Work Area, and Stiffness of 0.5% FLB SLN Gel and 5% Marketed FLB Gel

Article Snippet: Three groups: no treatment, 0.5% FLB SLN gel, and 5% FLB gel marketed product of SD rats (Envigo, IN, USA) were divide for this experiment.

Techniques: Adhesive

Journal: AAPS PharmSciTech

Article Title: Formulation of Topical Flurbiprofen Solid Lipid Nanoparticle Gel Formulation Using Hot Melt Extrusion Technique

doi: 10.1208/s12249-022-02410-w

Figure Lengend Snippet: Rheological studies of 0.5% w/v FLB SLN gel and 5% w/w FLB marketed gel formulation showing decrease in viscosity upon increase in shear rate

Article Snippet: Three groups: no treatment, 0.5% FLB SLN gel, and 5% FLB gel marketed product of SD rats (Envigo, IN, USA) were divide for this experiment.

Techniques: Formulation, Viscosity, Shear

Journal: AAPS PharmSciTech

Article Title: Formulation of Topical Flurbiprofen Solid Lipid Nanoparticle Gel Formulation Using Hot Melt Extrusion Technique

doi: 10.1208/s12249-022-02410-w

Figure Lengend Snippet: A In vitro permeation test (IVPT) showing significant increase in percent drug permeation in case of 0.5% w/v FLB SLN formulation as compared to 5% w/w FLB marketed gel formulation at the end of 24 h. B Skin deposition study showing significant increase in drug deposition in dermal layer in case of 0.5% w/v FLB SLN formulation as compared to 5% w/w FLB marketed gel formulation at the end of 24 h

Article Snippet: Three groups: no treatment, 0.5% FLB SLN gel, and 5% FLB gel marketed product of SD rats (Envigo, IN, USA) were divide for this experiment.

Techniques: In Vitro, Formulation

Journal: AAPS PharmSciTech

Article Title: Formulation of Topical Flurbiprofen Solid Lipid Nanoparticle Gel Formulation Using Hot Melt Extrusion Technique

doi: 10.1208/s12249-022-02410-w

Figure Lengend Snippet: In vivo anti-inflammatory study showing equivalent edema inhibition effect after application of 0.5% w/v FLB SLN gel and 5% w/w marketed FLB gel

Article Snippet: Three groups: no treatment, 0.5% FLB SLN gel, and 5% FLB gel marketed product of SD rats (Envigo, IN, USA) were divide for this experiment.

Techniques: In Vivo, Inhibition